Famotidine is a potent competitive inhibitor of H 2 histamine receptors. The primary clinically significant pharmacological activity of famotidine is inhibition of gastric secretion. Famotidine decreases as the concentration of hydrochloric acid and volume of gastric secretion, while changing secretion of pepsin proportional secreted by volume. In healthy volunteers and patients with hypersecretion oral primobolan famotidine inhibit basal and nocturnal acid secretion, and pepsinogen as well as secretion stimulated by administration of pentagastrin, betazola, caffeine, insulin and physiological reflex vagal nerve. antiandrogenic effect of the drug was observed.
Hypersensitivity to the active substance or to any of the excipients, pregnancy, lactation, children’s age.
Liver and / or kidney failure, cirrhosis with portosystemic encephalopathy (in history), immunodeficiency.
Application of pregnancy and lactation
famotidine crosses the placenta.
Controlled studies in humans have been conducted.
Famotidine is secreted in breast milk in humans; therefore breastfeeding during use should be discontinued.
The recommended dose is 20 mg of intravenous (i / v) twice a day (every 12 hours). In gastric ulcer and duodenal ulcer in the acute stage, hypersecretory states : / in slowly for 2 minutes to 20 mg 2 times / day in a diluted form; . i / v infusion: slowly over 15-30 min at 20 mg 2 times / day In reflux esophagitis the initial dose – 20 mg 2 times / day / in slowly. In Zollinger-Ellison syndrome: initial dose oral primobolan of 20 mg I / every 6 hours. Further: the dose depends on the amount of secretion and the clinical condition of the patient. When sheathe anesthesia to prevent aspiration of acidic gastric contents: is used in a dose of 20 mg / in the morning of surgery, or at least for 2 hours before the operation. The initial dose for intravenous administration may not exceed 20 mg. For intravenous injection of the contents of the vial should be dissolved in 5 – 10 ml 0.9% sodium chloride solution (solvent ampoule) and then slowly introduce (for at least 2 minutes). When infusion solution should be administered for 15-30 minutes. The solutions should be prepared immediately before administration. Only transparent colorless solution can be used. Use in renal failure. Since famotidine is excreted primarily by the kidneys, patients with severe renal insufficiency is necessary to take precautions. If creatinine clearance less than 30 mL / min and a serum creatinine concentration of greater than 3 mg / 100 ml, the daily dose should be reduced to 20 mg or longer intervals between injections before 36-48 hours. The use in children: Safety and efficacy in children not been established. The use in elderly patients: a dose Correction oral primobolan depending on age is required. eurochem labs