Symptomatic treatment of “cold” and flu (headache, muscle pain, sore throat, fever, cough, runny nose, stuffy nose and sinuses). Hypersensitivity to the drug or any of its components. Arterial hypertension, ischemic heart disease (coronary heart disease), angina. Severe hepatic or renal function, hepatitis. Concomitant use of primobolan results inhibitors (monoamine oxidase), antidepressants, antiparkinsonian drugs. The use of MAO inhibitors (monoamine oxidase) in the previous two weeks before receiving the drug initiated Congenital deficiency of glucose-6-phosphate dehydrogenase. Children under the age of 12 years. Pregnancy, lactation.
Precautions: benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholism, arrhythmia, prostatic hyperplasia primobolan results with urinary retention, diabetes, hyperthyroidism, bronchial asthma, COPD (chronic obstructive pulmonary disease), weakened and malnourished patients.
Dosage and administration The recommended dose Kaffetin Cold medication alpha pharma primo for adults and children over 12 years of age is one tablet four times a day. You can take 2 pills at once. The interval between doses should be at least 4 hours maximum single dose -. 2 tablets and the maximum daily dose – 2 tablets four times in 24 hours.
If the fever persists for more than 3 days from the start of treatment, and a cough for more than 5 days, you should consult a doctor.
Side effect From the digestive system: nausea, dry mouth, rare epigastric pain; long-term use in large dozah- hepatotoxicity. CNS: drowsiness, irritability, agitation, rarely – dizziness. Allergic reactions: skin rash, pruritus, urticaria, angioedema. Cardio-vascular system: increased blood pressure, tachycardia. From the side of hematopoiesis: rarely -anemiya, thrombocytopenia, agranulocytosis, long-term use in large dozah- hemolytic anemia, aplastic anemia, pancytopenia. From the urinary system: long-term use in large dozah- nephrotoxicity (renal colic, interstitial nephritis, papillary necrosis ).
Overdose symptoms. Pseudoephedrine – irritability, anxiety, tremors, convulsions, arrhythmias, hypertension. Paracetamol (especially in patients with impaired kidney and liver function) – pale skin, anorexia, nausea, vomiting, abnormal liver function. Dekstrometorfan- nausea, vomiting, dizziness, drowsiness, blurred vision, confusion, impaired coordination of movement, difficulty in breathing.
Treatment. Gastric lavage in the first 6 hours, followed by the appointment of activated charcoal, symptomatic therapy, the introduction of donators SH- groups and the synthesis of methionine precursor glutationa- in 8-9 hours after the overdose and atsetiltsisteina- 12 hours.
The interaction with other drugs Concomitant use of high doses of paracetamol enhances the effect of anticoagulant drugs. Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) and hepatotoxic drugs increases the production of hydroxylated active metabolites of paracetamol, which makes the possibility of severe intoxication, even at low doses.
Prolonged use of barbiturates, reduces the effectiveness of paracetamol. Simultaneous administration of paracetamol in prolonged high doses of salicylates and increases the risk of kidney cancer and bladder. Long-term sharing of paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of “analgesic” nephropathy and renal papillary necrosis, accelerates the onset of end-stage renal failure.
Diflunisal increases the plasma concentration of paracetamol by 50%, thereby increasing the risk of hepatotoxicity.
With simultaneous use of pseudoephedrine with other medications simlatomimeticheskimi possible additive effects and the development of toxic effects; with monoamine oxidase inhibitors – may develop a hypertensive crisis (use the drug may be no earlier than 2 weeks after discontinuation of monoamine oxidase inhibitors).
Propranolol may enhance the pressor effect of pseudoephedrine; Pseudoephedrine may decrease the hypotensive effect of reserpine, methyldopa, mecamylamine and hellebore alkaloids.
Amiodarone, fluoxetine, quinidine to inhibit the cytochrome P450 system, dextromethorphan can increase the concentration in the blood.
Cautions During treatment carried out monitoring of peripheral blood and functional state of the liver.
During the period of treatment should refrain from the use of ethanol (development of hepatotoxicity action) and caffeine, driving vehicles and occupation other potentially hazardous primobolan results activities that require high concentration and psychomotor speed reactions.
Form release tablets are film-coated.
10 tablets in a perforated aluminum foil blister and transparent three-layer film (PVC / TE / PVdC).
1 blister (10 tablets), together with instructions for use placed in a cardboard box.
Storage conditions Store at a temperature not exceeding 25 ° C, out of reach of children.
Shelf life 2 years. Do not use beyond the expiration date.
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