Hypersensitivity, primobolan steroid deficiency of glucose-6-phosphate dehydrogenase, pseudomembranous colitis, children’s age (up to 18 years – the completion of the formation of the skeleton), pregnancy, lactation.
Be wary – pronounced cerebral atherosclerosis, stroke, mental disorders, convulsions, epilepsy, severe renal and / or hepatic insufficiency, elderly age.
The drug should be administered intravenously over 30 minutes (200 mg) and 60 minutes (400 mg). Infusion solution can be combined with 0.9% sodium chloride solution, Ringer’s solution, 5% and 10% dextrose, 10% fructose solution, and a solution containing 5% dextrose solution with 0.225% or 0.45% sodium chloride solution .
Kvintora® dose depends on the severity of the disease, the type of infection, the body status, age, weight and kidney function in the patient. Recommended usual dose:
For intravenous single dose – 200 mg (in severe infections – 400 mg), the multiplicity of introduction – 2 times / day; the duration of treatment depends on the severity of the disease – 1-2 weeks, or more if necessary.
In acute gonorrhea -. 100 mg once intravenously
for prevention of postoperative infections – 30-60 minutes prior to surgery in / 200-400 mg.
From the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with a history of liver disease), hepatitis, gepatonekroz. From the nervous system: dizziness, headache, fatigue, anxiety, tremor insomnia, “nightmarish” dream, peripheral paralgeziya (anomaly perception of feeling pain), sweating, increased intracranial pressure, anxiety, confusion, depression, hallucinations, as well as others. manifestations of psychotic reactions (sometimes progressing to states in which the patient can cause self-harm), migraine, syncope, thrombosis of the cerebral arteries. From the senses: a violation of taste and smell, visual disturbances (diplopia, changes in color vision), tinnitus, hearing loss. From the CCC: tachycardia, cardiac arrhythmias, lowering blood pressure , rush of blood to the skin. From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, haemolytic anemia. From the laboratory parameters: hypoprothrombinemia, increased activity of “liver” transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia. With urinary system: hematuria, crystalluria (particularly in alkaline urine and low urine output), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, reduced azotvydelitelnoy renal dysfunction, interstitial nephritis. Allergic reactions: itching, rash, blistering, accompanied by bleeding, and small nodules, forming scabs, drug fever, petechial hemorrhages (petechiae), swelling of the face or throat, shortness of breath, eosinophilia, increased photosensitivity, vasculitis, nodular erythema, exudative erythema multiforme, Stevens-Johnson syndrome (malignant exudative erythema), toxic epidermal necrolysis (Lyell’s syndrome). Other: arthralgia, arthritis, tendonitis, tendon rupture, fatigue, myalgia, superinfection (candidiasis, pseudomembranous colitis), pain and burning sensation at the injection site, phlebitis.
A specific antidote is not known. It is necessary to carefully monitor the patient’s condition, gastric lavage, make routine emergency measures to ensure adequate intake of fluid. With hemodialysis or peritoneal dialysis can be displayed only minor (less than 10%) amount of the drug.
Due to the decreased activity of microsomal oxidation in hepatocytes, increases concentration primobolan steroid and lengthens T½ theophylline (et al. Xanthines, such as caffeine), oral hypoglycemic drugs, indirect anticoagulants, thereby reducing prothrombin index. NSAIDs (except ASA) increase the risk of seizures.
Metoclopramide accelerates the absorption, which leads to a decrease in the time to reach it the Cmax.
Co-administration of uricosuric drugs leads to excretion slow down (to 50%) and increase in the plasma concentration of ciprofloxacin.
When combined with others. Antimicrobials ( beta-lactams, aminoglycosides, clindamycin, metronidazole) commonly observed synergism; It can be successfully used in combination with azlocillin and ceftazidime in infections caused by Pseudomonas spp .; with mezlocillin, azlocillin and other beta-lactam antibiotics – in streptococcal infections.; with izoksazolpenitsillinami and vancomycin – with staphylococcal infections; metronidazole and clindamycin -. under anaerobic infections
Strengthens the nephrotoxic effect of cyclosporine, there is an increase in serum creatinine, therefore these patients should be monitored this indicator 2 times a week.
In simultaneous reception enhances the effect of anticoagulants.
The infusion solution is pharmaceutically compatible with all infusion solutions and drugs that physico-chemically unstable at an acidic environment (pH of the ciprofloxacin infusion solution – 3.5-4.6). You can not mix the solution for the on / in the introduction of a solution having a pH greater than 7.
If you encounter during or after treatment Kvintorom® severe and prolonged diarrhea should exclude the diagnosis of pseudomembranous colitis, which requires immediate discontinuation of the drug and appropriate treatment.
If you experience pain in the tendons, or when the first signs of tenosynovitis treatment should be discontinued.
In the period of treatment is necessary provide enough liquid under normal urine output.
during treatment should avoid contact with direct sunlight.
Effects on ability to drive vehicles and management mechanisms :
Patients taking primobolan steroid, caution should be exercised when driving and busy with other potentially hazardous activities that require increased attention and psychomotor speed reactions (especially with simultaneous use of alcohol).
Solution for infusion of 2 mg / ml. Plastic bottle of 100 ml in a plastic bag is packed in a cardboard box with instructions for use
In the dark place at a temperature no higher than 30 ° C. Do not freeze.
Keep out of reach of children.
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